Cheng Lei

Research Assistant Professor

Department of Chemistry

School of Science

The University of Tokyo

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    Cheng Lei (雷诚)

    Prof. Lei is now a research assistant professor of the Chemistry department of the University of Tokyo. His research interests include biomedical photonics, green photonics, ultrafast imaging, ultrafast spectroscopy, fiber optics, and radio over fiber. He received his bachelor's and Ph.D. degrees from Huazhong University of Science and Technology (HUST) and Tsinghua University on 2008 and 2013, respectively. He is a member of OSA (Optical Society of America), SPIE( International Society for Optics and Photonics). JSAP (The Japan Society of Applied Physics). He also serves as a referee for several journals, including OSA Optics Express, OSA Optics Letter, APL Photonics (AIP publishing), etc.

  • experiences

    Education

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    Tsinghua University

    September 2008 - July 2013

    Ph.D., Electronics Science and Technology

    Adviser: Prof. Minghua Chen

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    Huazhong University of Science and Technology

    September 2004 - July 2008

    B.S., Electronics and Information Engineering

    Adviser: Prof. Yu Liu

  • Professional experience

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    The University of Tokyo

    February 2015-Present

    Prof. Lei joined Goda Lab (Chemistry department, the University of Tokyo) in 2015 as a postdoc researcher. He mainly worked on biomedical photonics, green photonics, ultrafast imaging, ultrafast spectroscopy there. He was then promoted to be a research assistant professor on April 2017.

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    Tsinghua University

    July 2013 - January 2015

    Prof. Lei continued his research as a postdoc researcher on fiber optics and radio over fiber after he received the Ph.D. degree in Prof. Minghua Chen's lab. During that time, he started to extend his research interests to ultra-fast optical imaging.

  • Publications

    Journal publications

    1. Lei C*, Kobayashi H, Wu Y, Li M, Isozaki A, Yasumoto A, Mikami H, Ito T, Nitta N, Sugimura T, Yamada M, Yatomi Y, Di Carlo D, Ozeki Y, Goda K, "High-throughput imaging flow cytometry by optofluidic time-stretch microscopy," Nature Protocols 13: 1603-1631 (2018).
    2. Lei C, Goda K, “The complete optical oscilloscope,” Nature Photonics 12: 190-194 (2018).
    3. Nitta N, Sugimura T, Isozaki A, Mikami H, Hiraki K, Sakuma S, Iino T, Arai F, Endo T, Fujiwaki Y, Fukuzawa H, Hase M, Hayakawa T, Hiramatsu K, Hoshino Y, Inaba M, Ito T, Karakawa H, Kasai Y, Koizumi K, Lee S, Lei C, Li M, Maeno T, Matsusaka S, Murakami D, Nakagawa A, Oguchi Y, Oikawa M, Ota T, Shiba K, Shintaku H, Shirasaki Y, Suga K, Suzuki Y, Suzuki N, Tanaka Y, Tezuka H, Toyokawa C, Yalikun Y, Yamada M, Yamagishi M, Yamano T, Yasumoto A, Yatomi Y, Yazawa M, Di Carlo D, Hosokawa Y, Uemura S, Ozeki Y, Goda K, “Intelligent image-activated cell sorting” Cell 175: 1-11 (2018).
    4. Mikami H, Lei C, Nitta N, Sugimura T, Ito T, Ozeki Y, Goda K, “High-speed imaging meets single-cell analysis,” Chem (in press).
    5. 雷誠, 小林博文, 小関泰之, 合田圭介, “オプトフルイディックタイムストレッチ顕微法：最近の動向,” Optronics 3 (2018).
    6. Guo B, Lei C*, Wu Y, Kobayashi H, Ito T, Yalikun Y, Lee S, Isozaki A, Li M, Jiang Y, Yasumoto A, Di Carlo D, Tanaka Y, Yatomi Y, Ozeki Y, Goda K, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136: 116-125 (2018).
    7. Lei C*, Nitta N, Ozeki Y, Goda K, “Optofluidic time-stretch microscopy: recent advances,” Optical Review 25: 464-472 (2018).
    8. Kobayashi H, Lei C*, Wu Y, Mao A, Jiang Y, Guo B, Ozeki Y, Goda K, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Scientific Reports 7: 12454 (2017).
    9. 雷誠, 小関泰之, 合田圭介, “オプトフルイディック・タイムストレッチ顕微鏡と人工知能による大規模無標識 1 細胞解析 (生きたままを見る無染色バイオイメージング),” 光学 Japanese journal of optics: publication of the Optical Society of Japan, 46(7): 282-287, (2017).
    10. Jiang Y, Lei C*, Yasumoto A, Kobayashi H, Aisaka Y, Ito T, Guo B, Nitta N, Kutsuna N, Ozeki Y, Nakagawa A, Yatomi Y, Goda K, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab on a Chip 17(14): 2426-2434 (2017). (Cover paper & one of the top 10% of papers published in Lab on a Chip)
    11. Lei C, Wu Y, Sankaranarayanan A C, Chang S M, Guo B, Sasaki N, Kobayashi H, Sun C W, Ozeki Y, Goda K, “GHz optical time-stretch microscopy by compressive sensing,” Photonics Journal 9(2): 3900308, (2017).
    12. Guo B, Lei C*, Kobayashi H, Ito T, Yalikun Y, Jiang Y, Tanaka Y, Ozeki Y, Goda K, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytometry Part A, (2017), (Accepted).
    13. Lei C, Guo B, Cheng Z, Goda K, “Optical time-stretch imaging: Principles and applications,” Applied Physics Reviews 3(1): 011102, (2016).
    14. Lei C, Ito T, Ugawa M, Nozawa T, Iwata O, Maki M, Okada G, Kobayashi H, Sun X, Tiamsak P, Tsumura N, Suzuki K, Di Carlo D, Ozeki Y, Goda K, “High-throughput label-free image cytometry and image-based classification of live Euglena gracilis,” Biomedical Optics Express 7(7): 2703-2708, (2016).
    15. Lei C, Cheng Z, Goda K, “Cancer detection with high-throughput image cytometry,” Medical Imaging Technology 34(2): 68-75, (2016).
    16. 三上秀治, 雷誠, 鈴木祐太, 小関泰之, 合田圭介, “超高速イメージングで生命科学,” O plus E 38(10): 922-926, (2016).
    17. Li M, Muñoz H E, Schmidt A, Guo B, Lei C, Goda K, Di Carlo D, “Inertial focusing of ellipsoidal Euglena gracilis cells in a stepped microchannel,” Lab on a Chip 16(22): 4458-4465, (2016).
    18. Lei C, Chen H, Xing F, Chen M, Yang S, Xie S, “Time-stretch high-speed microscopic imaging system based on temporally and spectrally shaped amplified spontaneous emission,” Optics Letters 40(6): 946-949, (2015).
    19. Lei C, Chen H, Chen M, Yang S, Xie S, “Recirculating frequency shifting based wideband optical frequency comb generation by phase coherence control,” Photonics Journal 7(1): 1300107, (2015).
    20. Lei C, Chen H, Chen M, Yu Y, Guo Q, Yang S, Xie S, “Dynamic and balanced capacity allocation scheme with uniform bandwidth for OFDM-PON systems,” Optics Communications 338: 106-109, (2015).
    21. Ugawa M, Lei C, Nozawa T, Ideguchi T, Di Carlo D, Ota S, Ozeki Y, Goda K, “High-throughput optofluidic particle profiling with morphological and chemical specificity,” Optics Letters 40(20): 4803-4806, (2015).
    22. Xing F, Chen H, Lei C, Chen M, Yang S, Xie S, “A 2-GHz discrete-spectrum waveband-division microscopic imaging system,” Optics Communications 338: 22-26, (2015).
    23. Chen H, Lei C, Xing F, Weng Z, Chen M, Yang S, Xie S, “Multiwavelength time-stretch imaging system,” Optics Letters 39(7): 2202-2205, (2014).
    24. Yu Y, Lei C, Chen M, Chen H, Yang S, Xie S, “Generation and noise analysis of a wide-band optical frequency comb based on recirculating frequency shifter,” Chinese Optics Letters 12(10): 100601, (2014).
    25. Chen H, Li R, Lei C, Yu Y, Chen M, Yang S, Xie S, “Photonics-assisted serial channelized radio-frequency measurement system with Nyquist-bandwidth detection,” Photonics Journal 6(6): 7903707, (2014).
    26. Xing F, Chen H, Lei C, Weng Z, Chen M, Yang S, Xie S, “Serial wavelength division 1 GHz line-scan microscopic imaging,” Photonics Research 2(4): B31-B34, (2014).
    27. Li R, Chen H, Lei C, Yu Y, Chen M, Yang S, Xie S, “Optical serial coherent analyzer of radio-frequency (OSCAR),” Optics Express 22(11): 13579-13585, (2014).
    28. Yu H, Chen M, Gao H, Lei C, Zhang H, Yang S, Chen H, Xie S, “Simple photonic-assisted radio frequency down-converter based on optoelectronic oscillator,” Photonics Research 2(4): B1-B4, (2014).
    29. Lei C, Chen M, Chen H, Yang S, Yu Y, Xie S, “1 Tb/s WDM-OFDM-PON system with sub-band access scheme and flexible subcarrier-level bandwidth allocation,” Photonics Journal 5(1): 7900208, (2013)
    30. Gao H, Lei C, Chen M, Xing F, Chen H, Xie S, “A simple photonic generation of linearly chirped microwave pulse with large time-bandwidth product and high compression ratio,” Optics Express 21(20): 23107-23115, (2013).
    31. Liang Y, Chen M, Chen H, Lei C, Li P, Xie S, “Photonic-assisted multi-channel compressive sampling based on effective time delay pattern,” Optics Express 21(22): 25700-25707, (2013).
    32. Lei C, Chen H, Chen M, Xie S, “16×10Gb/s symmetric WDM-FOFDM-PON realization with colorless ONUs,” Optics Express 19(16): 15275-15280, (2011).
    33. Lei C, Chen H, Chen M, Xie S, “A high spectral efficiency optical OFDM scheme based on interleaved multiplexing,” Optics Express 18(25): 26149-26154, (2010).
    34. Xin M, Yin F, Lei C, Chen M, Chen H, Tang C, Xie S, “Broadband tunable optical delay based on real-time Fourier transformation and ramp-type phase modulation,” Optics Letters 35(10): 1596-1598, (2010).

    Conference publications

    1. Lei C, Ozeki Y, Goda K, “Time-stretch imaging: recent advances and trends,” The 17th International Conference on Optical Communications and Networks (ICOCN) (2018) (Invited).
    2. Lei C, Ozeki Y, Goda K, “Time-stretch imaging and beyond,” The 13th Pacific Rim Conference on Lasers and Electro-Optics (CLEO-PR) (2018) (Invited).
    3. Lei C, Ozeki Y, Goda K, “Optofluidic time-stretch microscopy for precision medicine,” OSA CLEO: Science and Innovations, (2018) (Invited).
    4. 小林博文, 雷 誠, 小関泰之, 合田圭介, “無標識明視野画像による全血中のがん細胞薬剤応答評価,” 応用物理学会秋季学術講演会 (2018).
    5. Zhou Y, Yasumoto A, Lei C, Yatomi Y, Goda K, “Analysis of platelet anti-coagulation by optofluidic time-stretch microscopy,” The 79th JSAP Autumn Meeting (2018).
    6. Wu Y, Lei C, Ozeki Y, Goda K, “Time-stretch quantitative phase imaging for cancer detection,” The 79th JSAP Autumn Meeting (2018).
    7. Lei C, Kobayashi H, Ozeki Y, Goda K, “Extreme-throughput imaging flow cytometry at 1,000,000 cells per second,” 33rd Congress of the International Society for Advancement of Cytometry (2018).
    8. Lei C, Kobayashi H, Ozeki Y, Goda K, “Optofluidic time-stretch microscopy with an extreme throughput of 1 million cells/s,” SPIE Photonics Europe (2018).
    9. Lei C, Kobayashi H, Jiang Y, Wu Y, Guo B, Yasumoto A, Ito T, Yatomi Y, Ozeki Y, Goda K, “Machine-learning-assisted optofluidic time-stretch microscopy for drug discovery and medical diagnostics,” SPIE Photonics West (2018).
    10. Lei C, Kobayashi H, Mao A, Jiang Y, Wu Y, Guo B, Ozeki Y, Goda K, “Label-free sensing of cellular drug responses by machine learning,” CYTO Asia (2017).
    11. Lei C, Guo B, Jiang Y, Kobayashi H, Ito T, Yasumoto A, Yatomi Y, Ozeki Y, Goda K, “Optofluidic time-stretch microscopy for high-throughput label-free imaging flow cytometry,” 32nd Congress of the International Society for Advancement of Cytometry (2017).
    12. Lei C, Guo B, Jiang Y, Wu Y, Kobayashi H, Ito T, Yasumoto A, Yatomi Y, Ozeki Y, Goda K, “High-throughput, label-free, multivariate cell analysis with optofluidic time-stretch microscopy,” The Pacific Rim Conference on Lasers and Electro-Optics (CLEO-Pacific Rim) (2017).
    13. Jiang Y, Lei C, Yasumoto A, Ozeki Y, Yatomi Y, Goda Y, “Label-free investigation of agonist-activated platelet aggregation with optofluidic time-stretch microscopy,” The 97th Chemical Society of Japan Annual Meeting (2017).
    14. Guo B, Lei C, Ito T, Yaxiaer Y, Kobayashi H, Jiang Y, Tanaka Y, Ozeki Y, Goda K, “Optofluidic time-stretch quantitative phase microscopy of Euglena gracilis,” The 97th Chemical Society of Japan Annual Meeting (2017).
    15. Guo B, Lei C, Ito T, Ozeki Y, Goda K, “High-throughput label-free screening of Euglena gracilis with optofluidic time-stretch quantitative phase microscopy,” SPIE Photonics West (2017).
    16. Jiang Y, Lei C, Yasumoto A, Ito T, Guo B, Kobayashi H, Ozeki Y, Yatomi Y, Goda K, “High-throughput label-free platelet aggregation detection with optofluidic time-stretch microscopy for thrombosis diagnosis,” SPIE Photonics West (2017).
    17. Kobayashi H, Lei C, Mao A, Jiang Y, Guo B, Goda K, “Label-free image-based detection of drug resistance with optofluidic time-stretch microscopy,” SPIE Photonics West (2017).
    18. Guo B, Lei C, Ito T, Jiang Y, Ozeki Y, Goda K, “Optofluidic time-stretch quantitative phase microscopy for high-throughput label-free single-cell screening,” SPIE Photonics West (2017).
    19. Lei C, Guo B, Ito T, Ozeki Y, Goda K, “High-speed optofluidic time-stretch microscopy for high-throughput label-free cell classification,” The 31st International Congress on High-Speed Imaging and Photonics (ICHSIP) (2016).
    20. Lei C, Ito T, Di Carlo D, Ozeki Y, Goda K, “High-throughput optofluidic microalgal cell analyzer with single-cell resolution for biofuel production,” SPIE/COS Photonics Asia (2016) (Invited).
    21. Lei C, Ito T, Di Carlo D, Ozeki Y, Goda K, “High-throughput single-cell image analysis of living Euglena gracilis for efficient biofuel production,” OSA CLEO: Science and Innovations (2016).
    22. Lei C, Ugawa M, Nozawa T, Ideguchi T, Di Carlo D, Ota S, Ozeki Y, Goda K, “High-throughput time-stretch microscopy with morphological and chemical specificity,” SPIE Photonics West (2016) (Best Paper Award)
    23. Lei C, Ugawa M, Nozawa T, Di Carlo D, Ozeki Y, Goda K, “High-throughput optofluidic microparticle analyzer based on time-stretch imaging,” The 63rd JSAP Spring Meeting (2016).
    24. Guo B, Lei C, Ito T, Jiang Y, Ozeki Y, Goda K, “High-throughput optofluidic profiling of Euglena gracilis with morphological and chemical specificity,” In SPIE/COS Photonics Asia (2016).
    25. Kobayashi H, Lei C, Mao A, Jiang Y, Guo B, Goda K, “Morphology-based cancer detection with optofluidic time-stretch,” SPIE/COS Photonics Asia (2016).
    26. Oikawa M, Hiyama D, Hirayama R, Hasegawa S, Endo Y, Sugie T, Tsumura N, Kuroshima M, Maki M, Okada G, Lei C, Ozeki Y, Goda K, Shimobaba T, “A computational approach to real-time image processing for serial time-encoded amplified microscopy,” SPIE Photonics West (2016).
    27. Lei C, Chen M, Chen H, Yang S, Xie S, “A colorless ONU scheme for WDM-OFDM-PON with symmetric bitrate and low-cost direct-detection receivers,” OSA CLEO: Science and Innovations, (2015).
    28. Weng Z, Chen H, Guo Q, Lei C, Chen M, Yang S, Xie S, “Line-scan time domain single-pixel camera,” OSA Novel Techniques in Microscopy (2015).
    29. Lei C, Chen H, Li R, Chen M, Yang S, Xie S, “Instantaneous broadband RF signal acquisition based on optical serial coherent analyzer (OSCAR),” SPIE/COS Photonics Asia (2014) (Invited).
    30. Lei C, Chen H, Li R, Chen M, Yang S, Xie, S, “Optical serial coherent analyzer of radio-frequency (OSCAR),” In Progress in Electromagnetics Research Symposium, (2014) (Invited).
    31. Lei C, Chen H, Li R, Chen M, Yang S, Xie S, “Broadband high-resolution programmable radio frequency signal analysis,” SPIE Newsroom (2014).
    32. Lei C, Chen H, Chen M, Yang S, Xie S, “Recirculating frequency shifting based photonic-assisted broadband instantaneous radio-frequency measurement,” OSA CLEO: Applications and Technology, (2014).
    33. Lei C, Yu Y, Chen M, Chen H, Yang S, Xie S, “Temporally controlled wideband optical frequency comb generation based on recirculating frequency shifting,” IEEE Microwave Photonics (MWP) and the 9th Asia-Pacific Microwave Photonics Conference (APMP) (2014).
    34. Wang D, Lei C, Chen M, Chen H, Yang S, Xie S, “A flexible allocation fast OFDM passive optical network system based on bit and power loading,” OSA Asia Communications and Photonics Conference (ACP) (2014).
    35. Wang D, Lei C, Chen H, Chen M, Yang S, Xie S, Luo R, “16QAM optical fast-OFDM transmission system based on discrete Fourier transform and frequency multiplexing,” The 19th Optoelectronics and Communications Conference (OECC) and the 39th Australian Conference on Optical Fibre Technology (ACOFT) (2014).
    36. Xing F, Chen H, Lei C, Chen M, Yang S, Xie S, “A 2-GHz line scan time-stretch imaging system based on multi-wavelength source,” The 19th Optoelectronics and Communications Conference (OECC) and the 39th Australian Conference on Optical Fibre Technology (ACOFT) (2014) (Best Student Paper Award).
    37. Chen H, Weng Z, Liang Y, Lei C, Xing F, Chen M, Xie S, “High speed single-pixel imaging via time domain compressive sampling,” In OSA CLEO: Applications and Technology (2014).
    38. Lei C, Chen H, Chen M, Yang S, Xie S, “High-speed laser scanner with tunable scan rate, wavelength resolution and spectral coverage,” OSA CLEO: Applications and Technology (2013).
    39. Yu Y, Lei C, Chen M, Chen H, Yang S, Xie S, “Bit and power loading strategy for OFDM-PON with uniform transmission performance,” OSA Asia Communications and Photonics Conference (ACP), (2013) (Best Student Paper Award).
    40. Guo Q, Lei C, Chen M, Chen H, Yang S, Xie S, “Dynamic transmission capacity allocation for sub-band-access OFDM-PON system,” OSA Asia Communications and Photonics Conference (ACP), (2013).
    41. Gao H, Lei C, Chen M, Xing F, Chen H, Xie S, “Photonics generation of linearly chirped electrical pulse with ultra-wide frequency band up to THz,” IEEE Microwave Photonics (MWP) (2013).
    42. Li R, Lei C, Liang Y, Chen H, Chen M, Yang S, Xie S, “Serial photonic channelized RF frequency measurement based on optical coherent frequency scanning,” OSA Opto Electronics and Communications Conference (OECC) and International Conference on Photonics in Switching (PS) (2013).
    43. Lei C, Chen H, Chen M, Xie S, “Experimental demonstration of a 16-user, 10-Gbps symmetric WDM-OFDM-PON system with colorless ONUs,” The 7th Asia-Pacific Microwave Photonics Conference (APMP), (2012).
    44. Yu Y, Lei C, Chen M, Chen H, Yang S, Wu S, Xie S, “90-tone stable optical frequency comb generation using a recirculating frequency shifter,” OSA Asia Communications and Photonics Conference (ACP) (2012).
    45. Chen H, Lei C, Chen M, Xie S, “Terabit all optical sampling OFDM system,” OSA Information Optoelectronics, Nanofabrication and Testing (2012).
    46. Lei C, Chen H, Fan P, Chen M, Xie S, “A novel carrier reuse scheme for colorless OFDM-PON with 10Gb/s symmetric transmission,” Opto-Electronics and Communications Conference (OECC) (2011) (Best Student Paper Award).
    47. Lei C, Chen H, Chen M, Xie S, “A 10Gb/s DFT based fast optical OFDM scheme with double spectral efficiency,” OSA CLEO: Applications and Technology (2011).
    48. Lei C, Tang C, Chen H, Chen M, Xie S, “Improving O-OFDM system performance with constellation fine adjustment,” OSA Asia Communications and Photonics Conference (ACP) (2010).
    49. Yin F, Xin M, Lei C, Chen H, Chen M, Xie S, “Tunable broadband optical delay using phase modulation,” OSA Conference on Lasers and Electro-Optics (2010).

    Invited presentations

    1. The 17th International Conference on Optical Communications and Networks (ICOCN), Zhuhai China (2018)
    2. The 13th Pacific Rim Conference on Lasers and Electro-Optics (CLEO-PR), Hong Kong, China (2018)
    3. OSA CLEO: Science and Innovations, San Jose, USA (2018)
    4. SPIE/COS Photonics Asia, Beijing, China (2016)
    5. Progress in Electromagnetics Research Symposium, Guangzhou, China (2014)
    6. SPIE/COS Photonics Asia, Beijing, China (2014)

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